This is happening for me too. I just installed the Advanced Custom Fields plugin.
I set up a check box field. It displays on my edit page. I can change the value and update the page. The check box displays its default value instead of the saved value as soon as the edit page refreshes.
The value of the field is saved though. My template responds appropriately.
It could cause a bunch of confusion with my editors if the right state of the setting is not displayed on the edit page.
Any ideas?
P.S. The problem seems to be happening in Chrome and Firefox (didn’t try IE).