@wyerstuff — I couldn’t agree more with @lightenup. Genesis is a great theme framework, but if you want to make lots of customizations, you’ll probably find yourself knee-deep in code.
I recommend you check out Headway. It uses a visual editor so you can customize fonts, colors, etc. without diving into CSS. As well, Headway is drag-and-drop, so changing the layout is easy too. And, as of the latest version, it’s responsive.
I’ve also heard great things about Responsive; will be testing it myself in the next couple of weeks.
Best of luck.
