Best practice to work with Async Javascript and Autoptimize

Hi,

I’m always confused by this:
So I use Async Javascript to async/defer scripts on my site, and use Autoptimize to combine/minify scripts and styles. For compatible reason, I have to exclude some certain scripts and styles from these two plugins.
WPFC was activated and configured before these two are deployed. WPFC works just fine with all my other plugins, that is I don’t have to exclude any script/style. Then I disabled WPFC and deployed Async Javascript and Autoptimize (excluded some files from these two), after this, I enable WPFC again.

The question is, as Autoptimize has done the combine/minify part, so combine and minify should be turned off in WPFC. However, as some files are excluded from those two, if I keep combine/minify on in WPFC, will it still be worth considering those excluded files shall be further combined/minified by WPFC?

I leave combine/minify to on in WPFC for now, website seems to be fine. Just curious though.

Thank you.