Can't open WordPress anymore

I get the following error message

Warning: require_once(/home/httpd/vhosts/naehbistro.ch/httpdocs//wp-includes/load.php) [function.require-once]: failed to open stream: No such file or directory in /home/httpd/vhosts/naehbistro.ch/httpdocs/wp-load.php on line 46

Fatal error: require_once() [function.require]: Failed opening required ‘/home/httpd/vhosts/naehbistro.ch/httpdocs//wp-includes/load.php’ (include_path=’.:/usr/share/pear:/usr/share/php’) in /home/httpd/vhosts/naehbistro.ch/httpdocs/wp-load.php on line 46

I have edited the General Information, where I have to insert the URL. Maybe it’s now wrong.
In which file is this information stored ? How can I modify ? Maybe can I restore it ?