Hide Plugins

At first, you can only hide plugin menu items or areas. You can’t change the capability for the access of a plugin.

In the multisite is the difference, if the plugin is network wide active, that you save all setting in the global settings, usable from all sites.
If you like difference in the settings for each site, activate the plugin not network wide, activate it in each blog and the plugin save the settings in each blog for each blog. If you have a lot of options, use the ex/import option to share settings from an blog to an other blog.