THAT, is a good question
I don’t have access to test on NGINX, so invite you to try it
WP Roids doesn’t make any database edits except for one scheduled task being registered
It edits .htaccess too. Those are the only two intrusions it makes
Activate and see is all I can say. If s**t hits fan, simply deactivate and all should be well
Then let me know what happened and I can look to incorporate NGINX…
To follow up on this;
As WP Roids edits and relies upon .htaccess it should work if using NGINX as a reverse proxy, keeping Apache functionality
If NGINX is used standalone I doubt it would work, unless you can duplicate the rewrite rules from .htaccess onto the server
Reference: https://codex.ww.wp.xz.cn/Nginx
New release of WP Roids – anticipated Saturday 28 January – has a fix to serve static HTML cache files via PHP if .htaccess fails
HTH
Phil 🙂