Supporting Multisite?

Re Buddypress, MobiLoud is designed for a news site or a blog, but you can still load any webpage in a screen inside the app. So it does depend on what kind of app you’re trying to build. You can build a news app and add a page for activity in a forum via Buddypress, but it won’t be a good fit for a social network kind of app.

Regarding Multisite, you can install the plugin and it will work fine when activate at the site level. It needs to be activate on each site though.