User Custom Multiple Query/Filer

Anyone know of a plugin that will allow me to accomplish something like this… http://www.danieltulp.nl/work/quicksand-multiple.htm

I have tried every quicksand, taxonomy drilldown, custom query plugin I can find, but I can’t find anything that will let my users filter hundreds of posts with multiple filters.

This is another great example…
http://isotope.metafizzy.co/demos/combination-filters.html except instead of shapes I want to filter posts categorized in 3 different ways.

Thank you