zeleke

<?php
$latestPost = new WP_Query();
$latestPost->query('showposts=1');
while ($latestPost->have_posts()) : $latestPost->the_post();
?>
...
<?php endwhile; ?>

<?php
$page = (get_query_var('paged')) ? get_query_var('paged') : 1;
query_posts("paged=$page");
while (have_posts()) : the_post();
?>
...
<?php endwhile(); ?>

The first loop styles the post differently.